P2X7 receptor: Death or life?

The P2X7 ATP receptor in the kidney: a matter of life or death?

P2X7 is an intriguing membrane receptor for the extracellular nucleotide ATP, which functions as a ligand-gated ion channel; it can activate cell membrane permeabilization and also has a wide range of downstream signaling pathways, including mediation of inflammatory responses and modulation of cell turnover. Despite recent identification of P2X7 receptor protein in the renal tract, the biologi...

The P2X7 Receptor Supports Both Life and Death in Fibrogenic Pancreatic Stellate Cells

The pancreatic stellate cells (PSCs) have complex roles in pancreas, including tissue repair and fibrosis. PSCs surround ATP releasing exocrine cells, but little is known about purinergic receptors and their function in PSCs. Our aim was to resolve whether PSCs express the multifunctional P2X7 receptor and elucidate how it regulates PSC viability. The number of PSCs isolated from wild type (WT)...

Suspended life or extending death?

Oxygen cylinders: "life" or "death"?

Oxygen is crucial to maintain and save human life. Other than medical purposes it is widely used for manufacture of mineral water, fabrication works and other industrial activities. If adequate precautionary measures are not adopted while handling, storage or transport of oxygen cylinder or container, accidental blast may claim human life and other damage as well. The case involving three victi...

Evaluating Life or Death Prospects

Luc Bovens and Marc Fleurbaey Economics and Philosophy / Volume 28 / Special Issue 02 / July 2012, pp 217 ­ 249 DOI: 10.1017/S0266267112000235, Published online: 29 August 2012 Link to this article: http://journals.cambridge.org/abstract_S0266267112000235 How to cite this article: Luc Bovens and Marc Fleurbaey (2012). EVALUATING LIFE OR DEATH PROSPECTS. Economics and Philosophy, 28, pp 217­249 ...